Optimizing therapeutic efficacy of antifungal peptides via strategic terminal amino acid modification
Capping Gly at the N-terminus increased residue length while significantly enhancing the helical propensity of W4, thereby augmenting its antifungal activity. Our exploratory study demonstrated the potential strategies and avenues for optimizing the structure-function relationships of AFPs and developing highly effective antifungal drugs.
Authors
- A. S. Shan (ORCID: https://orcid.org/0000-0001-9357-9514)
- Licong Zhang (ORCID: https://orcid.org/0000-0002-8807-5378)
- Jiajun Wang (ORCID: https://orcid.org/0000-0002-2086-2105)
- Shanshan Zhang (ORCID: https://orcid.org/0000-0003-0814-7173)
- Junya Xing
- Jing Song (ORCID: https://orcid.org/0000-0002-7814-8318)
Institutions
- Northeast Agricultural University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1016/j.jare.2024.09.017
- Citations
- 12
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 4.14
Funders
- National Natural Science Foundation of China