Simultaneous Determination of Methotrexate Concentrations in Human Plasma and Cerebrospinal Fluid Using Two-Dimensional Liquid Chromatography: Applications in Primary Central Nervous System Lymphoma
The developed method was useful for therapeutic drug monitoring of MTX and suitable for assessing the risks and benefits of chemotherapy in patients with primary central nervous system lymphoma. Intravenous mannitol did not increase MTX concentration in the CSF of patients.
Authors
- Jing Shi (ORCID: https://orcid.org/0000-0001-9389-4055)
- Feng Wang
- Y Liu
- Hao Jiang (ORCID: https://orcid.org/0000-0002-8845-4378)
- Ji Ma
- Yan Hong Wang
- Qiang He
Institutions
- Central South University (CN)
- Shandong Tumor Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- World Journal of Oncology
- Published
- 2024-09-23
- DOI
- https://doi.org/10.14740/wjon1910
- Citations
- 4
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 2.17