A Comparative Analysis of ADRs under Obeticholic Acid and Ursodeoxycholic Acid in Cholestatic Liver Diseases Using the FAERS Database
This study reveals distinct safety profiles for OCA and UDCA in the treatment of PBC. OCA is associated with a higher frequency of pruritus, fatigue, constipation, and increased blood alkaline phosphatase levels, while UDCA is linked to hepatocellular carcinoma and type I hypersensitivity reactions. These findings support personalized treatment approaches based on individual patient characteristics.
Authors
- Mengqing Zhu (ORCID: https://orcid.org/0000-0001-9422-6550)
- Linghui Tao (ORCID: https://orcid.org/0009-0006-0448-4534)
- Yongsheng Zhang (ORCID: https://orcid.org/0000-0002-5827-8967)
- Feiye Zhu
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Drug Research
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1055/a-2401-4700
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00