Mycophenolate mofetil directly modulates myeloid viability and pro-fibrotic activation of human macrophages
For the first time, we have demonstrated that MMF inhibits the viability and pro-fibrotic activation of human monocytes and macrophages, which is dependent on de novo purine synthesis. Coupled with myeloid gene expression attenuation following MMF treatment in patients, these results suggest that the fibrotic inhibition observed with MMF may be attributable, at least in part, to direct effects on myeloid cells.
Authors
- Nicole M. Orzechowski (ORCID: https://orcid.org/0000-0001-7494-5240)
- Patricia Ann Pioli (ORCID: https://orcid.org/0000-0001-6896-7259)
- Rezvan Parvizi (ORCID: https://orcid.org/0000-0001-8650-1225)
- Michael L. Whitfield (ORCID: https://orcid.org/0000-0002-0862-6003)
- Emily A. Morris (ORCID: https://orcid.org/0009-0009-7002-6226)
Institutions
- Dartmouth College (US)
- University of North Carolina at Chapel Hill (US)
- Dartmouth Psychiatric Research Center (US)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1093/rheumatology/keae517
- Citations
- 3
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Science Foundation
- Dartmouth College
- National Institutes of Health
- Norris Cotton Cancer Center
- National Cancer Institute
- National Institute of General Medical Sciences