Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation

In patients with nonvalvular AF and a prior thromboembolic event despite taking OAT, LAAO was associated with a lower risk of ischemic stroke compared with continued OAT alone. Randomized clinical trial data are needed to confirm that LAAO may be a promising treatment option for this population with a very high risk of stroke.

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Publication Details

Journal
JAMA Neurology
Published
2024-09-23
DOI
https://doi.org/10.1001/jamaneurol.2024.2882
Citations
22
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
Field-Weighted Citation Impact
8.84

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article

Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation

Joyce Peper, Alessandro Beneduce, Kamil Zieliński, Alexandros A. Polymeris et al.
22 citations
JAMA Neurology
Atrial Fibrillation Management and Outcomes
8.84
article

Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation

Joyce Peper, Alessandro Beneduce, Kamil Zieliński, Alexandros A. Polymeris, James T. Maddux, Pradhum Ram, Sohei Yoshimura, Shoji Arihiro, Ḱazunori Toyoda, Venkata Alla, Kasper Korsholm, Georgios K. Tsivgoulis, Alessio Gasperetti, Tobias Bobinger, Mikhael F. El‐Chami, Martin M. Brown, Maurizio Paciaroni, Valeria Caso, Ole De Backer, Rodrigo Estévez‐Loureiro, Claudio Tondo, Daniel B. Spoon, Pedro Cepas‐Guillén, Berenice Caneiro‐Queija, Philippe Lyrer, Masatoshi Koga, Nicolai Fierro, Xavier Freixa, Maria Rita Romeo, Manuel Cappellari, Keith W. Muir, Solomon O. Badejoko, Errol W. Aarnink, Michele Venti, Sebastian Thilemann, Sérgio Luis Berti, Stefan Schwab, Martin J. Swaans, Andrea Alberti, Hiroshi Yamagami, Ingo Eitel, Gareth Ambler, Pablo Salinas, Vincent F. van Dijk, Stefan T. Engelter, Bernd Kallmünzer, Dabit Arzamendi, Radosław Pracoń, Gian Marco De Marchis, Bruno Bonetti, Abdul H. Almakadma, Patrizio Mazzone, Manabu Inoue, Marianna Adamo, Duncan Wilson, Kosmas Macha, Leo Hermann Bonati, Annaelle Zietz, David Julian Seiffge, Luis Nombela-Franco y, Moniek Maarse, Marcin Demkow, Lucas V.A. Boersma, Hussam Suradi, Tomas Benito‐González, Riccardo Altavilla, Rashaad Chothia, Trevor Simard, Xavier Millán Álvarez, David R. Holmes, David John Werring, Armando Pérez de Prado, Mohamad Adnan Alkhouli, Monica Acciarresi, Shoichiro Sato, Giancarlo Agnelli, Christina Paitazoglou, Nils Peters, Martin Bergmann, Paolo Bovi, Benno J. Rensing, Hans Jager, Masahito Takagi, Himanshu Agarwal, Luca Branca, Jens Erik Nielsen-Kudsk
article en
22 citations

Abstract

In patients with nonvalvular AF and a prior thromboembolic event despite taking OAT, LAAO was associated with a lower risk of ischemic stroke compared with continued OAT alone. Randomized clinical trial data are needed to confirm that LAAO may be a promising treatment option for this population with a very high risk of stroke.

JAMA NeurologyVol. 81(11)
Creighton University (US), Rush University Medical Center (US), Mayo Clinic (US), Johns Hopkins University (US), Vita-Salute San Raffaele University (IT), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), University of Basel (CH), University of Milan (IT), Providence College (US), University of Perugia (IT), Emory University Hospital (US), University Hospital of Bern (CH), Hospital de Sant Pau (ES), Aarhus University Hospital (DK), University Hospital Complex Of Vigo (ES), University Hospital of Basel (CH), Rigshospitalet (DK), Christchurch Hospital (NZ), Hospital Clínico San Carlos (ES), Asklepios Klinik Altona (DE), Universitätsklinikum Erlangen (DE), Centro Cardiologico Monzino (IT), Azienda Ospedaliera Universitaria Integrata Verona (IT), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES), New Zealand Brain Research Institute (NZ), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), St. Antonius Ziekenhuis (NL), National Cerebral and Cardiovascular Center (JP), Hospital Clínic de Barcelona (ES), Felix Platter-Hospital (CH), German Centre for Cardiovascular Research (DE), Institute of Cardiology (PL), Metropolitana Milanese (Italy) (IT), National Hospital for Neurology and Neurosurgery (GB), Amsterdam University Medical Centers (NL), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Corona (Poland) (PL), St. Joseph Medical Center (US), Fondazione Toscana Gabriele Monasterio (IT), Hospital Universitario de León (ES), University College London (GB), University of Brescia (IT), University of Lübeck (DE)
Emory University, Creighton University, Aarhus Universitet, Aarhus Universitetshospital, Universität Basel, Rush University, Deutsches Zentrum für Herz-Kreislaufforschung, National Cerebral and Cardiovascular Center, Rigshospitalet, Università degli Studi di Brescia, Università degli Studi di Perugia
Openalex Percentile: Top 2%
Atrial Fibrillation Management and Outcomes
8.84
DOIOpen Access PDFOpenAlex
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