RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus
The findings indicate that elevated RTP4 exacerbates HSV-1 infection by enhancing its binding to corneal epithelial cells, whereas Rtp4 knockdown mitigated corneal lesions in T2D mice. This implies RTP4 as a potential target for intervention in diabetic HSV-1 infection.
Authors
- Hongqi Ge
- Lingling Yang (ORCID: https://orcid.org/0000-0002-6211-8042)
- Qingjun Zhou (ORCID: https://orcid.org/0000-0002-7770-9275)
- Shilan Mao
- Jing Feng (ORCID: https://orcid.org/0000-0001-6726-7912)
- Xinyi Zang
- Xiaolei Wang (ORCID: https://orcid.org/0000-0003-3403-1174)
- Xia Qi
- Yalin Wang
- Yunhai Dai (ORCID: https://orcid.org/0000-0002-5904-4548)
Institutions
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1167/iovs.65.11.36
- Citations
- 4
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province