CDK5 affects the resistance of lung cancer to radiotherapy by altering the tumor microenvironment

This article aims to explore the impact of cyclin-dependent kinase 5 (CDK5) on the tumor microenvironment and its influence on radiotherapy resistance in lung cancer through bioinformatics analysis. Initially, dataset GSE148532 identifying 517 differentially expressed genes, with 67 downregulated and 450 upregulated. Functional enrichment analysis revealed these genes are primarily concentrated in the extracellular matrix. KEGG analysis indicated significant enrichment in the TGF-beta signaling pathway and cytokine-cytokine receptor interactions. Using Cytoscape, three key networks and the top ten intermediary genes were identified. Immune infiltration analysis showed significant correlations between CDK5 expression and macrophages, neutrophils, and dendritic cells.