Progressive 11β-Hydroxysteroid Dehydrogenase Type 2 Insufficiency as Kidney Function Declines
A continuum of declining 11βHSD2 activity was observed with progressively lower eGFR in individuals spanning a wide spectrum of kidney function, including those with apparently normal kidney function. These findings implicate cortisol-mediated MR activation in the pathophysiology of hypertension and cardiovascular disease in CKD.
Authors
- Thomas Uslar (ORCID: https://orcid.org/0000-0001-7213-855X)
- David G. Stouffer (ORCID: https://orcid.org/0009-0008-9453-8819)
- René Baudrand
- Carlos Fardella (ORCID: https://orcid.org/0000-0002-5500-4434)
- Fidel Allende (ORCID: https://orcid.org/0000-0002-6508-4052)
- Richard Joseph Auchus (ORCID: https://orcid.org/0000-0001-6815-6181)
- Alejandra Tapia-Castillo (ORCID: https://orcid.org/0000-0002-6081-1468)
- Michael D. Cherney (ORCID: https://orcid.org/0000-0001-8422-5319)
- Anand Vaidya (ORCID: https://orcid.org/0000-0002-0314-9252)
- Sandra Solari
- Jenifer M. Brown (ORCID: https://orcid.org/0000-0002-6647-639X)
- Cristián A. Carvajal (ORCID: https://orcid.org/0000-0002-0668-412X)
- Julia Milks
- Laura C Tsai (ORCID: https://orcid.org/0009-0008-5344-2589)
- Andrew J Newman (ORCID: https://orcid.org/0000-0002-8326-1964)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Pontificia Universidad Católica de Chile (CL)
- University of Michigan (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1210/clinem/dgae663
- Citations
- 8
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- American Heart Association
- Agencia Nacional de Investigación y Desarrollo
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases