Self‐ and study partner–reported cognitive decline in older adults without dementia: The role of α‐synuclein and amyloid biomarkers in the Alzheimer's Disease Neuroimaging Initiative
Cerebrospinal fluid α-synuclein (α-syn) seed amplification assay was used to determine α-syn positivity. Amyloid beta (Aβ)-/α-syn-, Aβ-/α-syn+, Aβ+/α-syn-, and Aβ+/α-syn+ biomarker groups were created. Aβ+/α-syn+ had greater subjective cognitive decline (SCD) than the other biomarker groups. Aβ-/α-syn+ did not differ from Aβ-/α-syn- across self- or study-partner reported SCD scores. Study partner-reported subjective memory results were largely driven by participants with mild cognitive impairment.
Authors
- Alexandra J. Weigand (ORCID: https://orcid.org/0000-0002-7931-1383)
- Lindsay J. Rotblatt (ORCID: https://orcid.org/0000-0002-2854-577X)
- Douglas R Galasko (ORCID: https://orcid.org/0000-0001-6195-3241)
- Lauren Edwards (ORCID: https://orcid.org/0000-0002-8434-9669)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- Katherine J. Bangen
Institutions
- University of California, San Francisco (US)
- San Diego State University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1002/alz.14239
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Institute on Aging