Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity
TDO2 is more highly expressed than the nonhomologous TRP-catabolizing enzyme IDO1 in TNBC. We find that TDO2 knockdown can lead to a compensatory increase in IDO1. Therefore, we tested a newly developed TDO2/IDO1 dual inhibitor and found that it decreases TRP catabolism, anchorage-independent survival, and invasive capacity.
Authors
- Benjamin G. Bitler (ORCID: https://orcid.org/0000-0002-5809-5271)
- Julie A. Reisz (ORCID: https://orcid.org/0000-0002-7296-4963)
- Micaela Kalani Roy (ORCID: https://orcid.org/0000-0002-1045-6752)
- Kathleen O’Neill (ORCID: https://orcid.org/0000-0001-7681-2863)
- Jennifer K. Richer (ORCID: https://orcid.org/0000-0002-9960-0991)
- Lyndsey S. Crump (ORCID: https://orcid.org/0000-0003-2790-7780)
- Andrew E. Goodspeed (ORCID: https://orcid.org/0000-0001-7055-7128)
- Meher P. Boorgula (ORCID: https://orcid.org/0000-0003-4700-4140)
- Angelo D’Alessandro (ORCID: https://orcid.org/0000-0002-2258-6490)
- Nicole S. Spoelstra (ORCID: https://orcid.org/0009-0003-3981-5960)
- Michelle M. Williams (ORCID: https://orcid.org/0000-0002-7063-9147)
- Mike Bickerdike (ORCID: https://orcid.org/0009-0004-1415-4200)
- Li‐Wei Kuo (ORCID: https://orcid.org/0000-0002-1135-8740)
- Jessica L. Christenson (ORCID: https://orcid.org/0000-0002-6311-8191)
- Amy Argabright
Institutions
- University of Pittsburgh (US)
- University of Colorado Cancer Center (US)
- Antisense Therapeutics (Australia) (AU)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0272
- Citations
- 4
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.63
Funders
- National Science Foundation
- U.S. Department of Defense
- Colorado State University
- National Institutes of Health
- Cancer Center, University of Colorado
- Anschutz Medical Campus, University of Colorado
- National Cancer Institute
- BioFrontiers Institute, University of Colorado Boulder