Margination of artificially stiffened red blood cells
Margination, the migration of leukocytes to the vessel wall, is a well-known physiological process. However, the role of cell stiffness in this phenomenon remains unclear. Our study investigates the segregation of stiffened red blood cells (RBCs) within healthy cell suspensions. Unexpectedly, we found central and corner peaks in the stiffened RBC distribution and a nonmonotonic dependency on the flow rate. Length scales for margination are found to be much longer than typical distances between bifurcations in-vivo, questioning the importance of margination in physiological situations.
Authors
- Othmane Aouane (ORCID: https://orcid.org/0000-0002-5267-1629)
- Jens Harting (ORCID: https://orcid.org/0000-0002-9200-6623)
- Christian Wagner (ORCID: https://orcid.org/0000-0001-7788-4594)
- Revaz Chachanidze (ORCID: https://orcid.org/0000-0001-6748-6197)
- Marc Léonetti
Institutions
- Centre National de la Recherche Scientifique (FR)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Luxembourg (LU)
- Aix-Marseille Université (FR)
- Helmholtz Institute Erlangen-Nürnberg (DE)
- Centre Interdisciplinaire de Nanoscience de Marseille (FR)
- Saarland University (DE)
Publication Details
- Journal
- Physical Review Fluids
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1103/physrevfluids.9.l091101
- Citations
- 5
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Centre National d’Etudes Spatiales
- Deutsch-Französische Hochschule