Insights into small-molecule compound CY-158-11 antibacterial activity against <i>Staphylococcus aureus</i>
The combination of the rising incidence of antibiotic resistance and the shrinking antibiotic pipeline has raised concern about the postantibiotic era. New antibacterial agents and targets are required to combat <i>S. aureus</i>-associated infections. In this study, we identified a maleimide-diselenide hybrid compound CY-158-11 exhibiting antibacterial activity against <i>S. aureus in vitro</i> and <i>in vivo</i> at relatively low concentrations. Furthermore, the investigation of its mode of action revealed that CY-158-11 can selectively perturb the cytoplasmic membrane of bacteria without harming mammalian cells or mouse organs. Thus, CY-158-11 is a compelling novel drug for development as a new therapy for <i>S. aureus</i> infections.
Authors
- Jianbo Lv
- Haojin Gao
- Xinru Yuan
- Rongrong Hu (ORCID: https://orcid.org/0000-0002-7939-6962)
- Jingyi Yu (ORCID: https://orcid.org/0000-0002-3380-1053)
- Yanghua Xiao
- Fangyou Yu (ORCID: https://orcid.org/0000-0003-4924-2484)
- Peiyao Zhou
- Junhong Shi
- Shen Li (ORCID: https://orcid.org/0000-0002-3022-1141)
- Weihua Han (ORCID: https://orcid.org/0009-0003-3285-3905)
- Jiao Zhang (ORCID: https://orcid.org/0000-0001-9920-107X)
- Yü Huang (ORCID: https://orcid.org/0000-0002-1277-6784)
- Cailing Wan
- Bingjie Wang (ORCID: https://orcid.org/0009-0003-8361-5843)
Institutions
- Tongji University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- mSphere
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1128/msphere.00643-24
- Citations
- 5
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- National Natural Science Foundation of China
- Tongji University
- Shanghai Pulmonary Hospital