MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors

Collectively, our results provide a strong rationale and mechanistic insights for the clinical development of MRTX1719-based IO combinations in MTAP-loss tumors.

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Publication Details

Journal
Journal for ImmunoTherapy of Cancer
Published
2024-09-01
DOI
https://doi.org/10.1136/jitc-2024-009600
Citations
16
Primary Topic
Cancer-related gene regulation
Type
article
Field-Weighted Citation Impact
3.74

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article

MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors

Mark T. Bedford, Leilei Shi, Rongjie Fu, Jiakai Hou et al.
16 citations
Journal for ImmunoTherapy of Cancer
Cancer-related gene regulation
3.74
article

MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors

Mark T. Bedford, Leilei Shi, Rongjie Fu, Jiakai Hou, Jordi Rodón, Wei He, Everett Stone, Taiping Chen, Pooja A. Shah, Donjeta Gjuka, Ningbo Zheng, Si Chen, Cheng‐Tai Yu, Ashley Guerrero, Sana Sharif, Weiyi Peng, Ritu Bohat, Roshni Jaffery, Yue Lu, Shuyue Wang, Han Xu, Xinli Liu, Nicholas A. Egan
article en
16 citations

Abstract

Collectively, our results provide a strong rationale and mechanistic insights for the clinical development of MRTX1719-based IO combinations in MTAP-loss tumors.

Journal for ImmunoTherapy of CancerVol. 12(9)
The University of Texas MD Anderson Cancer Center (US), University of Houston (US), The University of Texas at Austin (US)
U.S. Department of Defense, American Cancer Society, Cancer Prevention and Research Institute of Texas, Melanoma Research Alliance, National Institutes of Health
Openalex Percentile: Top 6%
Cancer-related gene regulation
3.74
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