MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors
Collectively, our results provide a strong rationale and mechanistic insights for the clinical development of MRTX1719-based IO combinations in MTAP-loss tumors.
Authors
- Mark T. Bedford (ORCID: https://orcid.org/0000-0002-8899-1050)
- Leilei Shi (ORCID: https://orcid.org/0000-0002-9427-4357)
- Rongjie Fu
- Jiakai Hou (ORCID: https://orcid.org/0000-0003-2875-8756)
- Jordi Rodón (ORCID: https://orcid.org/0000-0001-6467-3632)
- Wei He (ORCID: https://orcid.org/0000-0002-3088-5650)
- Everett Stone (ORCID: https://orcid.org/0000-0002-2459-9762)
- Taiping Chen (ORCID: https://orcid.org/0000-0002-2524-6440)
- Pooja A. Shah (ORCID: https://orcid.org/0000-0001-5445-0443)
- Donjeta Gjuka
- Ningbo Zheng (ORCID: https://orcid.org/0000-0002-3684-5596)
- Si Chen (ORCID: https://orcid.org/0009-0007-7508-9619)
- Cheng‐Tai Yu
- Ashley Guerrero (ORCID: https://orcid.org/0009-0008-6393-9433)
- Sana Sharif (ORCID: https://orcid.org/0000-0001-5856-2186)
- Weiyi Peng (ORCID: https://orcid.org/0000-0002-7785-6240)
- Ritu Bohat (ORCID: https://orcid.org/0000-0001-6660-4235)
- Roshni Jaffery (ORCID: https://orcid.org/0000-0003-4128-345X)
- Yue Lu
- Shuyue Wang (ORCID: https://orcid.org/0000-0001-7470-0999)
- Han Xu (ORCID: https://orcid.org/0000-0002-8654-461X)
- Xinli Liu (ORCID: https://orcid.org/0000-0002-1680-1561)
- Nicholas A. Egan (ORCID: https://orcid.org/0009-0003-7662-9817)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of Houston (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2024-009600
- Citations
- 16
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- U.S. Department of Defense
- American Cancer Society
- Cancer Prevention and Research Institute of Texas
- Melanoma Research Alliance
- National Institutes of Health