Sulfa-Michael Addition on Dehydroalanine: A Versatile Reaction for Protein Modifications
Chemical modification of proteins has been widely applied in diagnostic and therapeutic processes. Here, we report a novel bioconjugation between sulfinic acids and amino acid dehydroalanine (Dha) in the context of both small molecules and proteins. This conjugation enables the rapid formation of sulfone linkages in a chemoselective and disulfide-compatible manner under biocompatible conditions with Dha residues chemically installed in proteins and thus provides a robust tool that is simple and has exquisite site selectivity for protein functionalization in a wide range.
Authors
- Chunrong Liu (ORCID: https://orcid.org/0000-0002-9240-0380)
- Hongen Geng
- Man Li (ORCID: https://orcid.org/0009-0002-1464-1995)
- Mengzhao Li (ORCID: https://orcid.org/0000-0003-4029-9484)
- Xiang Li (ORCID: https://orcid.org/0000-0003-0356-4066)
- Linfeng Chen (ORCID: https://orcid.org/0009-0006-9150-8898)
- Ludan Xu
Institutions
- Central China Normal University (CN)
- Hubei University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1021/acs.orglett.4c02970
- Citations
- 4
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities