Photoredox/NHC Dual Catalysis Enabled de Novo Synthesis of α-Amino Acids Derivatives
Herein, we report a mild and operationally simple photoredox/NHC dual catalysis strategy for the α-carboxylation of tertiary amine C(sp<sup>3</sup>)-H bonds using diethyl pyrocarbonate. This method offers a novel approach for synthesizing α-amino acid derivatives. The protocol features a broad substrate scope, accommodating both N-aryl tetrahydroisoquinolines (THIQ) and <i>N</i>-methyl aniline and is scalable to gram quantities. Additionally, it is suitable for the late-stage derivatization of certain pharmaceutical compounds.
Authors
- Chenxing Zhou
- Youwan Ye
- Yong Yuan (ORCID: https://orcid.org/0000-0003-3196-1747)
- Congde Huo (ORCID: https://orcid.org/0000-0002-3374-7931)
- Xiazhen Bao (ORCID: https://orcid.org/0000-0003-4658-4227)
- Xin Zhang (ORCID: https://orcid.org/0000-0003-2906-2670)
- Dongsheng Ji
Institutions
- Northwest Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1021/acs.orglett.4c03387
- Citations
- 7
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation