Cross‐protection of allergen immunotherapy‐induced antibodies to related allergens requires a high degree of structural identity
In summary, our findings suggest that a relatively high threshold of similarity is required to establish effective cross-blocking antibodies to related allergens. Apparently, the structural identity between Bet v 1 and Mal d 1 is below this threshold. Therefore, this study may explain why immunotherapy with birch pollen allergen often fails to reduce birch pollen-related apple allergy.
Authors
- Maria Regina Strobl (ORCID: https://orcid.org/0000-0001-8247-7408)
- Stephan Scheurer (ORCID: https://orcid.org/0000-0002-2859-562X)
- Christian Radauer (ORCID: https://orcid.org/0000-0001-9920-4449)
- Hilal Demir (ORCID: https://orcid.org/0009-0004-9708-8930)
- Barbara Bohle (ORCID: https://orcid.org/0000-0002-5105-7985)
- Tamar Kinaciyan (ORCID: https://orcid.org/0000-0002-8238-2561)
Institutions
- Medical University of Vienna (AT)
- Paul Ehrlich Institut (DE)
Publication Details
- Journal
- Allergy
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1111/all.16323
- Citations
- 6
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- Austrian Science Fund
- Universität Wien
- Medizinische Universität Wien