Microbiome signature suggestive of lactose-intolerance in rhesus macaques (Macaca mulatta) with intermittent chronic diarrhea
A lactose intolerance mechanism is suggested in these animals by the bloom of Lactobacillus in the presence of lactose resulting in an overproduction of intermediate fermentation products likely led to osmotically induced diarrhea. This study provides new insights into suspected microbiome-lactose intolerance relationship in rhesus macaques with intermittent chronic diarrhea. The integration of machine learning with metagenomic data analysis holds potential for developing targeted dietary interventions and therapeutic strategies and therefore ensuring a healthier and more resilient primate population.
Authors
- Frank H. J. Schuren (ORCID: https://orcid.org/0000-0001-6982-5340)
- Annemiek Maaskant (ORCID: https://orcid.org/0000-0002-5385-9906)
- Jaco Bakker (ORCID: https://orcid.org/0000-0001-6670-1887)
- R.C. Montijn
- Marcus C. de Goffau
- Edmond J. Remarque (ORCID: https://orcid.org/0000-0002-5412-6958)
- Jan A. M. Langermans (ORCID: https://orcid.org/0000-0002-4806-4412)
- Evgeni Levin (ORCID: https://orcid.org/0000-0002-0368-6146)
- Bas Voermans (ORCID: https://orcid.org/0000-0002-6187-070X)
- Nicole Plomp
- Antoine Smits
Institutions
- Netherlands Organisation for Applied Scientific Research (NL)
- Utrecht University (NL)
- Wellcome Sanger Institute (GB)
- Biomedical Primate Research Centre (NL)
- Amsterdam Neuroscience (NL)
- AkzoNobel (Netherlands) (NL)
- University of Amsterdam (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Animal Microbiome
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1186/s42523-024-00338-z
- Citations
- 6
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 3.30