Leveraging single-cell transcriptomic data to uncover immune suppressive cancer cell subsets in triple-negative canine breast cancers
The present study demonstrates a versatile and scalable approach to integrating and analyzing scRNA-seq data, which successfully identified immune-modulatory subsets of canine TNBC. It also revealed potential mechanisms through which TNBC promotes immune evasion in dogs. These findings are crucial for advancing the understanding of the immune pathogenesis of canine TNBC and may aid in the development of new immune-based therapeutic strategies.
Authors
- Nicholas Borcherding (ORCID: https://orcid.org/0000-0003-1427-6342)
- Woo‐Jin Song (ORCID: https://orcid.org/0000-0002-9195-551X)
- Myung‐Chul Kim (ORCID: https://orcid.org/0000-0003-3389-1244)
- Ryan Kolb (ORCID: https://orcid.org/0000-0001-6305-2885)
- Weizhou Zhang (ORCID: https://orcid.org/0000-0002-8236-0346)
Institutions
- Washington University in St. Louis (US)
- University of Florida Health (US)
- University of Florida (US)
- Jeju National University (KR)
- Florida College (US)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2024-09-23
- DOI
- https://doi.org/10.3389/fvets.2024.1434617
- Citations
- 4
- Primary Topic
- Veterinary Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Research Foundation
- National Research Foundation of Korea