Catalyst-Free Radical Carbosulfonylation of Enamides with Indoles, Aryldiazonium Tetrafluoroborates, and DABCO·(SO<sub>2</sub>)<sub>2</sub>
Herein, we have developed a catalyst-free four-component carbosulfonylation of enamides involving indoles, DABCO·(SO<sub>2</sub>)<sub>2</sub>, and aryldiazonium tetrafluoroborates for the preparation of various β-amidosulfone products in moderate to excellent yields. This approach features mild reaction conditions, high step-efficiency, and broad substrate scope, which provides a green and efficient strategy for carbosulfonyl difunctionalization of enamides. Based on the results of mechanism studies, a radical tandem reaction process is proposed for the transformation.
Authors
- Hao Cheng (ORCID: https://orcid.org/0000-0001-5210-5267)
- Jie Wu (ORCID: https://orcid.org/0000-0002-0967-6360)
- Changmei Zhang (ORCID: https://orcid.org/0000-0003-4490-9673)
- Danqing Zheng (ORCID: https://orcid.org/0000-0003-4712-0088)
- Shaoyu Li
- Yuanyuan An (ORCID: https://orcid.org/0000-0001-8882-8504)
Institutions
- Nanjing Tech University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1021/acs.orglett.4c03009
- Citations
- 8
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- China Academy of Space Technology