Anti-astmatic effect of ROCK inhibitor, GSK429286 A, in experimentally induced allergic airway inflammation.
GSK429286 A, an inhibitor of the ROCK pathway, exhibits significant anti-inflammatory and antiremodeling effects in a guinea pig model of allergic asthma. Indeed, we demonstrate its effect on suppressing airway hyperreactivity and reducing cough frequency. These findings suggest that GSK429286 A may be a promising therapeutic agent for allergic asthma, although further studies are needed to investigate its long-term efficacy, underlying mechanisms, and optimal dosing strategy.
Authors
- Jozef Mažerik
- Eduard Gondáš (ORCID: https://orcid.org/0000-0001-9014-5630)
- Soňa Bálentová (ORCID: https://orcid.org/0000-0003-0398-6779)
- Daniela Vargová (ORCID: https://orcid.org/0000-0002-7043-0968)
- Marta Jošková (ORCID: https://orcid.org/0000-0001-5089-4928)
- Soňa Fraňová (ORCID: https://orcid.org/0000-0001-8429-092X)
- Lukáš Smieško
- Michal Pokusa (ORCID: https://orcid.org/0000-0002-6313-5100)
- Martina Šútovská (ORCID: https://orcid.org/0000-0003-1826-0786)
- Matúš Dohál (ORCID: https://orcid.org/0000-0003-2025-2830)
Institutions
- Comenius University Bratislava (SK)
Publication Details
- Journal
- PubMed
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1177/03946320241282949
- Citations
- 3
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- Agentúra na Podporu Výskumu a Vývoja
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV