Overexpression of DTX1 inhibits D-GalN/TNF-α-induced pyroptosis and inflammation in hepatocytes by regulating NLRP3 ubiquitination
Our study revealed that DTX1 suppressed D-GalN/TNF-α-induced hepatocyte pyroptosis and inflammation by regulating NLRP3 ubiquitination.
Authors
- J.H. Gan (ORCID: https://orcid.org/0009-0008-9355-1181)
- Mingshui Liu (ORCID: https://orcid.org/0009-0007-7263-786X)
- Xiaoping Huang (ORCID: https://orcid.org/0000-0003-0916-2885)
- Jing Gu (ORCID: https://orcid.org/0000-0002-7904-2793)
- Li Chen (ORCID: https://orcid.org/0000-0001-6278-5438)
- Wei Sun (ORCID: https://orcid.org/0000-0002-8278-3488)
Institutions
- Soochow University (CN)
- Taizhou Second People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Toxicology Research
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1093/toxres/tfae145
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23