Metabolic and dopaminergic correlates of intellectual enrichment in de-novo Parkinson's disease patients
CR proxies demonstrated to correlate directly with dopaminergic function and inversely with metabolism in cerebellar hemispheres in de-novo PD patients. The present multi-modal approach including both metabolic and dopaminergic correlates of CR allowed to identify possible compensation mechanisms, highlighting a potential role of the cerebellum that deserves further investigation.
Authors
- Stefano Raffa
- Francesca D’Amico (ORCID: https://orcid.org/0000-0002-1859-8958)
- Maria Isabella Donegani (ORCID: https://orcid.org/0000-0003-1736-8410)
- Gianmario Sambuceti (ORCID: https://orcid.org/0000-0003-2979-6500)
- Matteo Bauckneht (ORCID: https://orcid.org/0000-0002-1937-9116)
- Francesco Lanfranchi (ORCID: https://orcid.org/0000-0002-6043-9627)
- Pietro Mattioli (ORCID: https://orcid.org/0000-0003-2563-5830)
- Nicola Girtler (ORCID: https://orcid.org/0000-0001-8119-8642)
- Guido Rovera (ORCID: https://orcid.org/0000-0003-1839-0206)
- Federico Massa (ORCID: https://orcid.org/0000-0001-5667-204X)
- Matteo Pardini (ORCID: https://orcid.org/0000-0002-4740-1982)
- Dario Arnaldi (ORCID: https://orcid.org/0000-0001-6823-6069)
- Silvia Daniela Morbelli (ORCID: https://orcid.org/0000-0002-7833-6095)
- Beatrice Orso (ORCID: https://orcid.org/0000-0001-9983-7940)
- Luca Sofia
Institutions
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Policlinico San Martino (IT)
- University of Turin (IT)
- University of Genoa (IT)
Publication Details
- Journal
- The Quarterly Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2024-09-01
- DOI
- https://doi.org/10.23736/s1824-4785.24.03585-4
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.37