Neuroprotective effect of Bouvardia ternifolia (Cav.) Schltdl via inhibition of TLR4/NF-κB, caspase-3/Bax/Bcl-2 pathways in ischemia/reperfusion injury in rats
The dichloromethane extract of <i>B. ternifolia</i> demonstrated significant neuroprotective effects in the BCCAO/reperfusion model by modulating multiple signaling pathways. It effectively reduced oxidative stress, inhibited inflammation, and attenuated apoptosis, primarily through the downregulation of key proteins and genes associated with these processes. These findings suggest that the extract holds therapeutic potential for mitigating ischemia/reperfusion-induced neuronal damage.
Authors
- Aída Araceli Rodríguez-Hernández (ORCID: https://orcid.org/0000-0001-9179-1888)
- Plácido Rojas-Franco (ORCID: https://orcid.org/0000-0002-3465-9212)
- Enrique Jiménez‐Ferrer (ORCID: https://orcid.org/0000-0002-0783-8274)
- Edgar Cano-Europa (ORCID: https://orcid.org/0000-0002-3536-5590)
- Gabriela Trejo‐Tapia (ORCID: https://orcid.org/0000-0002-7479-9332)
- Maribel Herrera‐Ruíz (ORCID: https://orcid.org/0000-0001-9056-3568)
- Yury Maritza Zapata-Lopera
Institutions
- Mexican Social Security Institute (MX)
- Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-23
- DOI
- https://doi.org/10.3389/fphar.2024.1471542
- Citations
- 3
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.70