Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond
Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently recommendations on intraoperative tissue procurement only exist for diffuse gliomas but management of other brain tumor subtypes can also benefit from these protocols. Fresh tissue from surgical resection can now be used for intraoperative diagnostics and functional precision medicine assays. A multidisciplinary neuro-oncology perspective is critical to develop the best avenues for practical standardization. This perspective from the multidisciplinary Oncology Tissue Advisory Board (OTAB) discusses current advances, future directions, and the imperative of adopting standardized protocols for diverse brain tumor entities. There is a growing need for consistent operating room practices to enhance patient care, streamline research efforts, and optimize outcomes.
Authors
- Bob S. Carter (ORCID: https://orcid.org/0000-0002-3586-1324)
- Charles G. Eberhart (ORCID: https://orcid.org/0000-0002-2910-9427)
- Joanna J. Phillips (ORCID: https://orcid.org/0000-0002-3789-8120)
- Costas G. Hadjipanayis (ORCID: https://orcid.org/0000-0002-1269-1668)
- Brent A. Orr (ORCID: https://orcid.org/0000-0003-0997-4728)
- Manmeet S. Ahluwalia (ORCID: https://orcid.org/0000-0003-3794-9511)
- Tom Mikkelsen
- Sunit Das (ORCID: https://orcid.org/0000-0002-2146-4168)
- William J. Shelton (ORCID: https://orcid.org/0000-0002-9892-6690)
- Andreas von Deimling (ORCID: https://orcid.org/0000-0002-5863-540X)
- Tomás Garzón-Muvdi (ORCID: https://orcid.org/0000-0002-2198-9757)
- Analiz Rodriguez (ORCID: https://orcid.org/0000-0003-3426-0508)
- James T. Rutka (ORCID: https://orcid.org/0000-0003-0851-7330)
- Cynthia Hawkins (ORCID: https://orcid.org/0000-0003-2618-4402)
- Thomas S. Jacques (ORCID: https://orcid.org/0000-0002-7833-2158)
- Graeme F. Woodworth (ORCID: https://orcid.org/0000-0001-9663-0768)
- Susan M. Chang
- Michael W. McDermott
- Chetan Bettegowda
- Henry Brem
- Alexander A. Khalessi
- David A. Solomon
- Mark L. Rosenblum
Institutions
- University of Maryland, Baltimore (US)
- Baptist Hospital of Miami (US)
- St. Michael's Hospital (CA)
- St. Jude Children's Research Hospital (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Emory University (US)
- Henry Ford Health System (US)
- University of San Diego (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Heidelberg University (DE)
- Johns Hopkins Medicine (US)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Hospital for Sick Children (CA)
- Massachusetts General Hospital (US)
- Miami Transplant Institute (US)
- Johns Hopkins Hospital (US)
- Neurological Surgery (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- University College London (GB)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-09-23
- DOI
- https://doi.org/10.3389/fonc.2024.1471257
- Citations
- 3
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Johns Hopkins University
- National Institute for Health and Care Research
- National Institutes of Health
- Great Ormond Street Institute of Child Health