Cytotoxic T-lymphocyte antigen 4 and programmed cell death ligand 1 blockade increases the effectiveness of interleukin-15 immunotherapy in a bovine leukemia model
The biological activity of rbIL15 is characterized by the induction of transcription factors and the production of IFN-γ. Using rbIL15 with CTLA-4 and PD-L1 blockade in PBMCs from healthy and BLV+ cows led to the production of a transcription factor and cytokine. The results demonstrate the possibility of using this method to improve immunity and immunological memory in patients with chronic viral infections.
Authors
- Malika Nurtleu (ORCID: https://orcid.org/0000-0002-1299-8782)
- Laura Tokhtarova (ORCID: https://orcid.org/0000-0003-4386-993X)
- Zhansaya Adish (ORCID: https://orcid.org/0000-0001-9527-8774)
- Kanatbek Mukantayev (ORCID: https://orcid.org/0000-0002-6048-0232)
- Kanat Tursunov (ORCID: https://orcid.org/0000-0001-8260-2563)
- Darkhan Kanayev (ORCID: https://orcid.org/0000-0001-9569-9034)
- Bisultan Abirbekov (ORCID: https://orcid.org/0009-0002-0971-9962)
Institutions
- L. N. Gumilyov Eurasian National University (KZ)
- National Center for Biotechnology (KZ)
Publication Details
- Journal
- Veterinary World
- Published
- 2024-09-01
- DOI
- https://doi.org/10.14202/vetworld.2024.2096-2103
- Citations
- 1
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.24