Expression, potential biological behaviour and clinical significance of MCM3 in pancreatic adenocarcinoma: a comprehensive study integrating high throughput sequencing, CRISPR screening and in-house immunohistochemistry
MCM3 is likely to be a critical element in promoting the initiation and growth of PAAD. Flavopiridol may exert its anti-PAAD effect through the interaction between MCM3, classic CDK1 targets in the cell cycle checkpoint and p53 pathway as well as related molecules in other pathways.
Authors
- Rong‐Quan He (ORCID: https://orcid.org/0000-0002-7752-2080)
- Jia‐Yuan Luo (ORCID: https://orcid.org/0000-0003-4712-5217)
- Jian‐Di Li (ORCID: https://orcid.org/0000-0001-7050-371X)
- Yi‐Wu Dang (ORCID: https://orcid.org/0000-0002-7793-1239)
- Gang Chen (ORCID: https://orcid.org/0000-0003-2402-2987)
- Liu-yan Li
- Zhi‐Guang Huang (ORCID: https://orcid.org/0000-0003-4457-9491)
- Wan-Ying Huang (ORCID: https://orcid.org/0000-0002-8314-5963)
- Yi Chen (ORCID: https://orcid.org/0000-0003-0236-7263)
- Dan‐Ming Wei
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1080/07853890.2024.2405879
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Guangxi Medical University
- Division of Undergraduate Education