Pharmacokinetics of anti-TB drugs in children and adolescents with drug-resistant TB: a multicentre observational study from India
Age significantly impacted the plasma concentration and exposure of moxifloxacin. The observed frequencies of suboptimal and supratherapeutic concentrations underscore the necessity for dose optimization and therapeutic drug monitoring in children and adolescents undergoing DR-TB treatment.
Authors
- Kannan Thiruvengadam (ORCID: https://orcid.org/0000-0002-3758-1094)
- Chandrasekaran Padmapriyadarsini (ORCID: https://orcid.org/0000-0002-1324-4595)
- Shanmugam M. Jeyakumar (ORCID: https://orcid.org/0000-0002-4500-8431)
- Zahabiya Nalwalla
- Sushant Mane (ORCID: https://orcid.org/0000-0001-9272-4361)
- Vikas Oswal
- Vishrutha Poojari (ORCID: https://orcid.org/0000-0002-4317-9288)
- Hemanth Kumar Agibothu Kupparam
- Prathiksha Giridharan (ORCID: https://orcid.org/0000-0002-9048-8905)
- Sangeeta Sharma (ORCID: https://orcid.org/0000-0001-7411-5335)
- Srushti Gandhi
- Vijayakumar Annavi
- Bharathi Raja Thangavelu
- Ira Shah
- Sarath Balaji Babu
- Suhbangi Mankar
- Asha Frederick
- Sudha Vilvamani
- S. Mahalingam
- Rathinam Sridhar
- Poorna Gangadevi Navaneethapandian
Institutions
- Government Medical College (IN)
- Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals (IN)
- Brihanmumbai Municipal Corporation (IN)
- Government Hospital of Thoracic Medicine (IN)
- LRS Institute of Tuberculosis and Respiratory Diseases (IN)
- Bai Jerbai Wadia Hospital for Children (IN)
- Tamil Nadu Board of Rural Development (IN)
- Institute of Child Health (IN)
- National Institute of Research in Tuberculosis (IN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1093/jac/dkae311
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Indian Council of Medical Research
- Iran Telecommunication Research Center