A Mendelian randomization study on causal relationship between metabolic factors and abnormal spermatozoa
Our MR analysis provides robust evidence that body fat percentage and resistin are risk factors for abnormal spermatozoa, suggesting implications of identifying them for potential interventions and clinical therapies in male infertility. Further investigation in larger-scale GWASs on subgroups of abnormal spermatozoa will verify impacts of metabolic factors on spermatogenesis.
Authors
- Xuelan Li (ORCID: https://orcid.org/0000-0001-9110-1103)
- Zhenhui Zhang (ORCID: https://orcid.org/0000-0001-7785-3851)
- Shuntian Guo
- Xin Chen (ORCID: https://orcid.org/0000-0001-7407-2929)
Institutions
- The First People's Hospital of Shunde (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Translational Andrology and Urology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.21037/tau-24-187
- Citations
- 1
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Southern Medical University