Rare germline chromosome 1 duplication identified in young male with colon cancer: a case report investigating causality
Our findings do not support that this duplication is a monogenetic cause of CRC, nor did a PRS point towards an increased risk in this 24-year-old male. Whether the duplication is a risk factor in combination with other genetic and non-genetic risk factors requires further studies.
Authors
- Thomas van Overeem Hansen (ORCID: https://orcid.org/0000-0003-4635-2653)
- Anna Byrjalsen (ORCID: https://orcid.org/0000-0002-3470-5995)
- Anne‐Marie Gerdes (ORCID: https://orcid.org/0000-0002-0328-3320)
- Karin Wadt (ORCID: https://orcid.org/0000-0003-2882-6798)
- Sara L. Garcia (ORCID: https://orcid.org/0000-0002-2784-2318)
- Line Borgwardt
Institutions
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2024-09-23
- DOI
- https://doi.org/10.21037/jgo-24-148
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00