TFAP2A-activated ITGB4 promotes lung adenocarcinoma progression and inhibits CD4+/CD8+ T-cell infiltrations by targeting NF-κB signaling pathway
<i>ITGB4</i> was transcriptionally activated by <i>TFAP2A</i>, and could promote LUAD progression and inhibit CD4<sup>+</sup>/CD8<sup>+</sup> T-cell infiltrations by activating the <i>NF-κB</i> signaling pathway. <i>ITGB4</i> may serve as a potential immunotherapeutic target of LUAD.
Authors
- Qi Wang (ORCID: https://orcid.org/0009-0006-7934-5707)
- Hongshun Wang (ORCID: https://orcid.org/0009-0002-5923-375X)
- Zhihua Li (ORCID: https://orcid.org/0000-0003-0348-6854)
- Zhibo Wang (ORCID: https://orcid.org/0000-0002-5804-3279)
- Cheng Pan (ORCID: https://orcid.org/0000-0002-8884-4405)
- Xiaheng Deng (ORCID: https://orcid.org/0000-0003-2817-6131)
- Liang Chen
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.21037/tlcr-24-50
- Citations
- 6
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.70