Employing Hexahydroquinolines as PfCDPK4 Inhibitors to Combat Malaria Transmission: An Advanced Computational Approach
Comparative analysis of this compound with BKI-1294 using advanced computational approaches demonstrated competitive potential. These findings suggest the potential of 4-[4-(Furan-2-carbonyl)piperazin-1-yl]-1-(naphthalen-2-ylmethyl)-2-oxo-4a,5,6,7,8,8a-hexahydroquinoline-3-carbonitrile as a promising <i>Pf</i>CDPK4 inhibitor for disrupting malaria transmission. However, further experimental studies are warranted to validate its efficacy and safety profile.
Authors
- Gbolahan O. Oduselu (ORCID: https://orcid.org/0000-0003-0136-1732)
- Olayinka O. Ajani (ORCID: https://orcid.org/0000-0002-3422-3478)
- Temitope A. Ogunnupebi (ORCID: https://orcid.org/0000-0002-0744-7812)
- Shopnil Akash
- Ezekiel Adebiyi (ORCID: https://orcid.org/0000-0002-1390-2359)
- Oluwadunni F Elebiju (ORCID: https://orcid.org/0000-0002-3005-7003)
Institutions
- German Cancer Research Center (DE)
- Covenant University (NG)
- Daffodil International University (BD)
- Heidelberg University (DE)
- Makerere University (UG)
Publication Details
- Journal
- Advances and Applications in Bioinformatics and Chemistry
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/aabc.s476404
- Citations
- 4
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.45