Targeting hexokinase 2 to enhance anticancer efficacy of trichosanthin in HeLa and SCC25 cell models
Our findings suggested that targeting HK2 and modulating glycolysis may offer a promising avenue for improving the therapeutic outcomes of TCS-based anticancer treatments.
Authors
- Yan Zhou (ORCID: https://orcid.org/0000-0003-4858-6648)
- Wenying Shan (ORCID: https://orcid.org/0000-0002-3922-1674)
- Kin Yip Tam (ORCID: https://orcid.org/0000-0001-5507-8524)
- Kaifang Wang (ORCID: https://orcid.org/0000-0003-0599-473X)
- Ou Sha (ORCID: https://orcid.org/0000-0003-1254-1683)
- Maoxin Ran
Institutions
- Shenzhen University (CN)
- University of Macau (MO)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2024-09-12
- DOI
- https://doi.org/10.5599/admet.2455
- Citations
- 3
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Science Foundation
- Science and Technology Foundation of Shenzhen City
- National Natural Science Foundation of China
- Universidade de Macau
- Fundo para o Desenvolvimento das Ciências e da Tecnologia
- National Natural Science Foundation of China-China Academy of General Technology Joint Fund for Basic Research