FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury
FGF21 promotes peripheral nerve repair by inhibiting ferroptosis caused by mitochondrial dysfunction. Therefore, targeting mitochondria and ferroptosis represents a promising therapeutic strategy for effective PNI repair.
Authors
- Jifeng Wang (ORCID: https://orcid.org/0000-0001-6457-7958)
- Yinuo Sun
- R. Wang
- Yuting Gu (ORCID: https://orcid.org/0000-0001-5891-0101)
- Zihan Zhou (ORCID: https://orcid.org/0009-0002-0227-9589)
- Yan Yao (ORCID: https://orcid.org/0000-0002-4003-4323)
- Xinyu Ran
- Jian Xiao
- Chuanqi Qiu
- Yingfeng Lu
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-23
- DOI
- https://doi.org/10.3389/fphar.2024.1358646
- Citations
- 13
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.71
Funders
- Wenzhou Medical University