Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling
These findings highlight the complex role of RAMPs in regulating PTH1R signalling and trafficking, revealing differential effects of RAMP2 and RAMP3 on receptor function. The data suggest that targeting the PTH1R/RAMP2 complex may be a promising strategy for developing novel bone anabolic therapies by leveraging biased agonism and functional selectivity. Further research using physiologically relevant models is needed to elucidate the therapeutic potential of this approach.
Authors
- David J. Roberts (ORCID: https://orcid.org/0000-0003-0648-6585)
- Ameera B. A. Jailani (ORCID: https://orcid.org/0000-0001-9837-6062)
- Timothy M. Skerry (ORCID: https://orcid.org/0000-0003-1319-5575)
- Paris Avgoustou (ORCID: https://orcid.org/0000-0002-1642-1083)
- Gareth O. Richards
- Aditya J. Desai (ORCID: https://orcid.org/0000-0002-0075-3470)
- Grant W. Stothard
- Ewan R. Lilley
Institutions
- University of Sheffield (GB)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-23
- DOI
- https://doi.org/10.3389/fphar.2024.1455231
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Biotechnology and Biological Sciences Research Council