Abnormal resting-state functional connectivity of hippocampal subregions in type 2 diabetes mellitus-associated cognitive decline
T2DACD showed a significant decrease in attentional inhibition and working memory, peripheral pro-inflammatory response increased, and abnormalities RSFC of the hippocampal subregions with default mode network and sensory-motor network. T2DM did not show a significant cognitive decline, but peripheral pro-inflammatory response increased and abnormalities RSFC of the hippocampus subregions occurred in the brain. In addition, the left precuneus may be a key brain region in the conversion of T2DM to T2DACD. The results of this study may provide a basis for the preliminary diagnosis of T2DACD.
Authors
- Haizhu Zheng
- Yanze Liu (ORCID: https://orcid.org/0000-0001-8858-8571)
- Kangcheng Wang (ORCID: https://orcid.org/0000-0002-3025-8294)
- Haipeng Huang (ORCID: https://orcid.org/0000-0001-5375-7558)
- Zhen Zhong (ORCID: https://orcid.org/0000-0003-0155-0752)
- Mengyuan Li (ORCID: https://orcid.org/0009-0003-9476-2734)
- Mingyi He (ORCID: https://orcid.org/0000-0003-2051-6955)
- Mengmeng Sun (ORCID: https://orcid.org/0000-0003-3470-7437)
- Hongfeng Wang (ORCID: https://orcid.org/0000-0002-3147-5581)
- Shiqi Ma
- Hongmei Yang (ORCID: https://orcid.org/0000-0002-9048-2546)
- Lin Yao
Institutions
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2024-09-23
- DOI
- https://doi.org/10.3389/fpsyt.2024.1360623
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Natural Science Foundation of Jilin Province
- National Natural Science Foundation of China
- People's Government of Jilin Province