Metabolic Reprogramming of CD4+ T Cells by Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuates Autoimmune Hepatitis Through Mitochondrial Protein Transfer
Disordered glucose metabolism promotes CD4<sup>+</sup> T-cell activation and associated inflammatory liver injury in AIH models, which can be reversed by MSC-EV therapy, and this effect is at least partially dependent on EV-mediated mitochondrial protein transfer between cells. This study highlights that MSC-EV therapy may represent a new avenue for treating autoimmune diseases such as AIH.
Authors
- Mengyi Shen
- Ruiqi Wu (ORCID: https://orcid.org/0000-0001-8020-0827)
- Shuyun Liu (ORCID: https://orcid.org/0000-0003-3865-4547)
- Li Yang (ORCID: https://orcid.org/0000-0003-3821-9342)
- Jingping Liu (ORCID: https://orcid.org/0000-0001-8364-639X)
- Leyu Zhou
- Xiaoli Fan (ORCID: https://orcid.org/0000-0002-8434-2969)
- Yanyi Zheng
- Qiaoyu Deng
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/ijn.s472086
- Citations
- 18
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.21