Identifying Potential Human Monoacylglycerol Lipase Inhibitors from the Phytoconstituents of Morinda Citrifolia L. Fruits by in silico Pharmacology and in vitro Study
Beta-sitosterol of <i>Morinda citrifolia</i> fruits may have the potential to protect human neurons by occupying the catalytic site of human MGL, thus competitively inhibiting the substrate of the enzyme. However, the inhibitory activity towards human MGL is lower than JZL195.
Authors
- Dwi Syah Fitra Ramadhan (ORCID: https://orcid.org/0000-0001-6257-7276)
- Adryan Fristiohady (ORCID: https://orcid.org/0000-0002-3499-0511)
- Nyi Mekar Saptarini (ORCID: https://orcid.org/0000-0002-2406-9411)
- Jutti Levita (ORCID: https://orcid.org/0000-0002-4578-4174)
- Asman Sadino (ORCID: https://orcid.org/0000-0002-2289-9729)
- Supat Jiranusornkul (ORCID: https://orcid.org/0000-0003-2368-9077)
Institutions
- Universitas Halu Oleo (ID)
- Universitas Garut (ID)
- Universitas Teknologi Sulawesi (ID)
- Institut Kesenian Makassar (ID)
- Chiang Mai University (TH)
- Padjadjaran University (ID)
Publication Details
- Journal
- Journal of Experimental Pharmacology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/jep.s477956
- Citations
- 1
- Primary Topic
- Morinda citrifolia extract uses
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Universitas Padjadjaran
- Direktorat Riset dan Pengabdian Masyarakat