Unveiling the Sleep-Immunity Nexus: Plant Bioresources for Ameliorating Consequences of Sleep Deprivation

Sleep is a fundamental physiological process that not only supports immune function but also contributes significantly to overall well-being. Because of the established decline in the average amount of sleep due to lifestyle and rise in shift work over the past few decades, exploring the relationship between sleep and immunity has become crucial. Moreover, infections trigger increased sleep as a result of the host's immunological response, particularly the release of proinflammatory cytokines, such as tumour necrosis factor and interleukin-1. Understanding the mechanisms governing the human immune response against different pathogens during sleep, as well as the neuroimmune interconnections, immune regulatory effects of sleep, and the impact of cytokines in sleep deprivation, is crucial. Traditional medicine has employed plant derived preparations for treating various sleep disorders and promoting better sleep. While some plant derived products have shown positive effects on sleep, it is essential to acknowledge the limited scientific research in this area, and altered individual responses to these. In conclusion, recognizing the critical connection between sleep and immunity underscores the importance of prioritizing sufficient and restorative sleep to bolster overall health and well-being. While certain products may offer potential benefits for better sleep, further scientific investigation is necessary to fully understand their effectiveness and applicability on an individual basis.