Preparation of Phosphorylated Chitosan From the Cuttlebone of Sepia pharaonis and the Effect of Concentration on Oral Clinical Pathogens

This work successfully used the cuttlebone of <i>S. pharaonis</i> to yield phosphorylated chitosan, subsequently demonstrating its antimicrobial potential against dental clinical pathogens. Different concentrations of phosphorylated chitosan strongly controlled its antimicrobial activity, with larger concentrations exhibiting stronger inhibitory effects. According to these findings, phosphorylated chitosan appears to be a promising material for dental care solutions that target clinical bacteria in the mouth.