Intervention of inflammation associated with ankylosing spondylitis by triptolide promotes histone H3 Iys-27 trimethylation
<b>Conclusion:</b> Triptolide inhibits Th17 cell differentiation via H3K27me3 upregulation and orchestrates changes in histone-modifying enzymes, including JMJD3 and EZH2. These findings support the clinical efficacy of triptolide for AS and may provide clues for identifying molecular targets for the development of novel treatments.
Authors
- Xiaohan Xu (ORCID: https://orcid.org/0000-0002-7754-7157)
- Junyi Jiang (ORCID: https://orcid.org/0000-0002-4080-069X)
- Jinxu Zhang (ORCID: https://orcid.org/0000-0001-7740-8686)
- Hongxiao Liu (ORCID: https://orcid.org/0000-0001-8734-7469)
- Zhe Zhao (ORCID: https://orcid.org/0000-0002-3680-0654)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- Guang’anmen Hospital (CN)
- Beijing Proteome Research Center (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2024-09-22
- DOI
- https://doi.org/10.1080/08923973.2024.2402911
- Citations
- 2
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality