Ag‐Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition of <i>N</i>‐2,2,2‐Trifluoroethylisatin Ketimines with Conjugated Exocyclic Double Bonds: Access to Pyrrolidines with Four Consecutive Stereocenters Including Two Adjacent Spiro‐Quaternary Centers

Abstract Ag‐catalyzed enantioselective 1,3‐dipolar cycloaddition of N ‐2,2,2‐trifluoroethylisatin ketimines with conjugated exocyclic double bonds including α ‐alkylidene succinimides and aurone derivatives was developed for the first time. Using a catalyst system consisting of a ferrocenyl P,N ‐ligand and AgNO 2 , the reaction provides a facile method for the construction of chiral pyrrolidines bearing four consecutive stereocenters and two adjacent spiro‐quaternary chiral centers, as well as offers a direct route to structurally diverse enantioenriched CF 3 ‐containing 3,2′‐pyrrolidinyl spirooxindole derivatives.