Ketamine Prevents Inflammation-Induced Reduction of Human Hippocampal Neurogenesis via Inhibiting the Production of Neurotoxic Metabolites of the Kynurenine Pathway
Results suggest that R- and S-ketamine have pro-neurogenic and anti-inflammatory properties; however, this is mediated by inhibition of the kynurenine pathway only in the context of IL-1b. Overall, this study enhances our understanding of the mechanisms underlying ketamine's antidepressant effects in the context of different inflammatory phenotypes, ultimately leading to the development of more effective, personalized therapeutic approaches for patients suffering from depression.
Authors
- Alessandra Borsini (ORCID: https://orcid.org/0000-0003-4410-7865)
- Gargi Mandal (ORCID: https://orcid.org/0000-0001-5767-4207)
- Silvia Alboni
- Nicole Mariani (ORCID: https://orcid.org/0000-0001-7918-3492)
- Carmine M. Pariante (ORCID: https://orcid.org/0000-0002-9132-5091)
- Madeline Kirkpatrick (ORCID: https://orcid.org/0009-0005-6187-8110)
Institutions
- University of Modena and Reggio Emilia (IT)
- King's College - North Carolina (US)
- King's College London (GB)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2024-09-18
- DOI
- https://doi.org/10.1093/ijnp/pyae041
- Citations
- 10
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.57
Funders
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Wellcome Trust
- National Institute for Health and Care Research
- King's College London
- European Commission
- H. Lundbeck A/S
- Medical Research Council