Black Americans With Sickle Cell Disease (SCD) Demonstrate Accelerated Epigenetic Pace of Aging Compared to Black Americans Without SCD
These data support our hypothesis that individuals with SCD experience accelerated biological aging as measured by global epigenetic variation. The assessment of epigenetic measures of biological aging may prove useful to identify which SCD patients would most benefit from clinical interventions to reduce mortality.
Authors
- Sarah L. Martindale (ORCID: https://orcid.org/0000-0002-0059-3454)
- Qing Yang (ORCID: https://orcid.org/0000-0003-4844-4690)
- Michelle F. Dennis (ORCID: https://orcid.org/0000-0003-0734-7448)
- Daniel Hatch (ORCID: https://orcid.org/0000-0003-0220-7059)
- Robin A. Hurley (ORCID: https://orcid.org/0009-0002-1720-9348)
- Rajendra A. Morey (ORCID: https://orcid.org/0000-0002-6517-6969)
- John J. Strouse (ORCID: https://orcid.org/0000-0003-0341-1457)
- Paula Tanabe (ORCID: https://orcid.org/0000-0001-9933-6425)
- Eric A. Dedert (ORCID: https://orcid.org/0000-0003-1301-7058)
- Kyle J. Bourassa (ORCID: https://orcid.org/0000-0001-9372-2309)
- Melanie E. Garrett (ORCID: https://orcid.org/0000-0003-2302-6150)
- Nathan A. Kimbrel (ORCID: https://orcid.org/0000-0001-7218-1005)
- Angela C. Kirby
- Jennifer C. Naylor (ORCID: https://orcid.org/0000-0003-2534-8700)
- Patrick S. Calhoun (ORCID: https://orcid.org/0000-0001-6739-6634)
- Scott D. Moore (ORCID: https://orcid.org/0000-0002-3357-695X)
- Marilyn J. Telen (ORCID: https://orcid.org/0000-0003-3809-1780)
- Allison E. Ashley‐Koch (ORCID: https://orcid.org/0000-0001-5409-9155)
- Scott D. McDonald (ORCID: https://orcid.org/0000-0003-1490-0096)
- Jared A. Rowland (ORCID: https://orcid.org/0000-0002-3655-3411)
- Mitchell R. Knisely (ORCID: https://orcid.org/0000-0002-2938-6125)
- Henry R. Wagner (ORCID: https://orcid.org/0000-0003-3954-6556)
- Tate F. Halverson (ORCID: https://orcid.org/0000-0003-0560-7576)
- Jason D. Kilts
- Brandy S. Martinez (ORCID: https://orcid.org/0000-0003-2441-2002)
- Charity I Oyedeji (ORCID: https://orcid.org/0000-0001-5179-7142)
- Jean C. Beckham (ORCID: https://orcid.org/0000-0001-8746-8949)
- Pallavi Aurora (ORCID: https://orcid.org/0000-0002-3038-8400)
- Eric B. Elbogen (ORCID: https://orcid.org/0000-0002-8341-8028)
- Elizabeth E. Van Voorhees (ORCID: https://orcid.org/0000-0003-3475-1737)
- Anna T. Magnante (ORCID: https://orcid.org/0000-0002-6489-8732)
- Nirmish Shah (ORCID: https://orcid.org/0000-0002-7506-0935)
- Robert D. Shura (ORCID: https://orcid.org/0000-0002-9505-0080)
- Brandon M. Lê (ORCID: https://orcid.org/0000-0002-6816-9641)
- Victoria O’Connor (ORCID: https://orcid.org/0000-0001-8922-2440)
- Christine E. Marx
- Faith S. Luyster
- Cindy Swinkels (ORCID: https://orcid.org/0009-0007-0221-5186)
- Harvey Jay Cohen
Institutions
- University of Pittsburgh (US)
- Duke University (US)
- Durham VA Health Care System (US)
- Duke Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2024-09-18
- DOI
- https://doi.org/10.1093/gerona/glae230
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Institutes of Health
- School of Medicine, Duke University
- Clinical Science Research and Development
- Geriatric Research Education and Clinical Center
- National Heart, Lung, and Blood Institute
- National Institute of Nursing Research
- NIH Clinical Center
- National Center for Advancing Translational Sciences