La(OTf)<sub>3</sub>‐Mediated [3+3]‐Annulation of Benzoxepines and Aminocrotonates: Easy Access to Bridged Bicyclic Benzoxepine Heterocycles†
Abstract A new and effective method for making bridged bicyclic benzoxepine derivatives were devised through the intermolecular [3+3]‐annulation of benzoxepine‐3‐carboxylates with aminocrotonates in the presence of La(OTf) 3 . The compounds were formed through reactions involving the benzoxepine moiety's C‐3 and C‐5 carbons to produce C−C and C−N bonds. One of the compound structure (±) 12‐ethyl‐6‐methyl‐3‐hydroxy‐5‐methyl‐2,3,4,7‐tetrahydro‐3,7‐methano benzo[ h ][1,4]‐oxazonine‐6,12‐dicarboxylate was confirmed by single crystal X‐ray analysis.
Authors
- Siva Hariprasad Kurma (ORCID: https://orcid.org/0000-0002-6597-192X)
- B. China Raju (ORCID: https://orcid.org/0000-0001-6905-809X)
- Sai Teja Kolla (ORCID: https://orcid.org/0000-0002-0133-8877)
- Balasubramanian Sridhar (ORCID: https://orcid.org/0000-0002-9682-8376)
Institutions
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-09-22
- DOI
- https://doi.org/10.1002/ejoc.202400655
- Citations
- 2
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.50