Hypoalbuminemia in children with acute lymphoblastic leukemia: relation to asparaginase therapy and impact on high dose methotrexate elimination
Low serum albumin is caused by concurrent asparaginase therapy and has a clinically significant impact on MTX disposition. Guidelines for administering HDMTX may need adjustment if serum albumin < 30 g/L, and, if possible, HDMTX courses should not be scheduled soon after asparaginase doses.
Authors
- Sophie Rex Christensen (ORCID: https://orcid.org/0000-0003-0722-8123)
- Laura B. Ramsey (ORCID: https://orcid.org/0000-0001-6417-3961)
- Steen Rosthøj (ORCID: https://orcid.org/0000-0002-6501-6260)
- Zachary L. Taylor (ORCID: https://orcid.org/0000-0001-5178-2397)
- Christina Friis Jensen (ORCID: https://orcid.org/0000-0002-5584-6148)
- Jesper Heldrup (ORCID: https://orcid.org/0000-0002-6211-1967)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Children's Mercy Hospital (US)
- Aalborg University Hospital (DK)
- Aalborg University (DK)
Publication Details
- Journal
- Cancer Chemotherapy and Pharmacology
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1007/s00280-024-04713-0
- Citations
- 9
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 4.89
Funders
- Aarhus Universitet
- Aarhus Universitetshospital
- Aalborg Universitetshospital