Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia
Our study uncovers an interplay between the cytokine milieu and transcriptional programs that extends a developmental window of permissiveness to transformation by the ETO2::GLIS2 AML fusion oncogene, controls the intratumoral cellular heterogeneity, and offers a ground-breaking therapeutical opportunity by a targeted combination strategy.
Authors
- Erika Brunet (ORCID: https://orcid.org/0000-0002-1726-4673)
- Fabien Boudia (ORCID: https://orcid.org/0000-0003-3156-504X)
- Thomas Mercher (ORCID: https://orcid.org/0000-0003-1552-087X)
- Guillaume Piton (ORCID: https://orcid.org/0000-0002-0124-0909)
- Vilma Barroca
- Nasséra Abermil (ORCID: https://orcid.org/0000-0002-0066-5884)
- Zakia Aid
- Laurent Renou (ORCID: https://orcid.org/0009-0005-7793-8544)
- Virginie Rouiller‐Fabre (ORCID: https://orcid.org/0000-0002-3927-5701)
- Arnaud Petit (ORCID: https://orcid.org/0000-0001-8363-1622)
- Verónica Alonso-Pérez (ORCID: https://orcid.org/0000-0002-2012-1307)
- Hélène Lapillonne (ORCID: https://orcid.org/0000-0002-6900-8313)
- Paola Ballerini (ORCID: https://orcid.org/0009-0005-4844-7762)
- Didier Busso (ORCID: https://orcid.org/0000-0003-3027-7900)
- Françoise Pflumio (ORCID: https://orcid.org/0000-0001-8995-596X)
- Delphine Moison
- Pierre Hirsch (ORCID: https://orcid.org/0000-0002-5300-2566)
- Jelena Martinović (ORCID: https://orcid.org/0000-0003-4595-7271)
- Rima Haddad (ORCID: https://orcid.org/0000-0001-7040-843X)
- Saryiami Devanand
- Christophe Metereau
- Elie Robert
- Loélia Babin (ORCID: https://orcid.org/0000-0002-0188-6582)
- Klaudia Galant
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Hôpital Armand-Trousseau (FR)
- Acute Leukemia French Association (FR)
- La Ligue Contre le Cancer (FR)
- CEA Paris-Saclay - Etablissement de Fontenay-aux-roses (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- CEA Paris-Saclay (FR)
- Centre de Recherche Saint-Antoine (FR)
- Hôpital Antoine-Béclère (FR)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1186/s12943-024-02110-y
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Société Française de lutte contre les Cancers et les leucémies de l'Enfant et de l'Adolescent
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Institut National Du Cancer
- Institut Gustave-Roussy
- Institut Carnot Santé Animale