Repeated LPS induces training and tolerance of microglial responses across brain regions
Together, findings support the dynamic regulation of microglia during the formation of immune memories in the brain and support future work to exploit this model in brain disease contexts.
Authors
- Justin Jao (ORCID: https://orcid.org/0000-0003-3926-0128)
- Juan A. Tamayo (ORCID: https://orcid.org/0000-0002-1037-8133)
- Annie Vogel Ciernia (ORCID: https://orcid.org/0000-0002-3406-3806)
- Kristen M. Lee (ORCID: https://orcid.org/0000-0003-4527-6468)
- Olivia Sullivan
- Paul Ashwood (ORCID: https://orcid.org/0000-0002-4255-1893)
- Abdullah M. Madany
- Jennifer Kim (ORCID: https://orcid.org/0000-0003-2922-1010)
- Brandon Wong
Institutions
- University of British Columbia Hospital (CA)
- Vancouver Coastal Health (CA)
- University of British Columbia (CA)
- Centre for Advancing Health Outcomes (CA)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1186/s12974-024-03198-1
- Citations
- 46
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 11.38
Funders
- Fondation Brain Canada
- Scottish Rite Charitable Foundation of Canada
- Michael Smith Health Research BC
- University of British Columbia
- Canadian Open Neuroscience Platform
- University of California, Davis
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- National Institute of Mental Health
- National Institute of Environmental Health Sciences