TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts
Our findings demonstrate a novel role of fibroblast-TRIM35 in cardiac remodeling and uncover the mechanism underlying SLC7A5-mediated amino acid transport and mTORC1 activation. These results provide a potential novel therapeutic target for treating cardiac remodeling.
Authors
- Liuhang Su
- Tingting Tong
- Suiji Li
- Chengxing Shen (ORCID: https://orcid.org/0000-0002-3882-7586)
- Juan Song (ORCID: https://orcid.org/0000-0001-5872-6806)
- Taixi Li (ORCID: https://orcid.org/0000-0002-7604-8137)
- Kaifan Niu
- Boshen Yang (ORCID: https://orcid.org/0000-0002-5294-1676)
- Yan Wang (ORCID: https://orcid.org/0000-0003-0671-7312)
- Zhixiang Wang (ORCID: https://orcid.org/0000-0002-6364-6891)
- Xian Jin (ORCID: https://orcid.org/0000-0001-5535-0460)
- Xia Lu (ORCID: https://orcid.org/0000-0001-6189-4202)
Institutions
- Shanghai Jiao Tong University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Nanjing Municipal Center for Disease Control And Prevention (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1186/s12964-024-01826-0
- Citations
- 11
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- National Natural Science Foundation of China