Site-discordant expression of myeloid cell nuclear differentiation antigen in blastic plasmacytoid dendritic cell neoplasm

Our findings suggest that MNDA expression in BPDCN is anatomic site dependent and transient, with noncutaneous infiltrates showing more frequent expression than cutaneous infiltrates. These results caution against the use of MNDA to exclude BPDCN when considering the differential diagnosis of a blastic extramedullary infiltrate.

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Publication Details

Journal
American Journal of Clinical Pathology
Published
2024-09-20
DOI
https://doi.org/10.1093/ajcp/aqae128
Primary Topic
Cutaneous lymphoproliferative disorders research
Type
article
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article

Site-discordant expression of myeloid cell nuclear differentiation antigen in blastic plasmacytoid dendritic cell neoplasm

Yasodha Natkunam, Kerri E. Rieger, Ryanne A. Brown, Atif Saleem et al.
American Journal of Clinical Pathology
Cutaneous lymphoproliferative disorders research
article

Site-discordant expression of myeloid cell nuclear differentiation antigen in blastic plasmacytoid dendritic cell neoplasm

Yasodha Natkunam, Kerri E. Rieger, Ryanne A. Brown, Atif Saleem, Sebastian Fernandez‐Pol, Philip L. Bulterys, Roberto A. Novoa
article en

Abstract

Our findings suggest that MNDA expression in BPDCN is anatomic site dependent and transient, with noncutaneous infiltrates showing more frequent expression than cutaneous infiltrates. These results caution against the use of MNDA to exclude BPDCN when considering the differential diagnosis of a blastic extramedullary infiltrate.

American Journal of Clinical PathologyVol. 163(3)
Stanford University (US)
Good health and well-being
Openalex Percentile: Top 67%
Cutaneous lymphoproliferative disorders research
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