Metastatic gastric adenocarcinoma discovered in the bone marrow

Gastric cancer primarily metastasizes to the peritoneum, liver and lungs, with bone marrow involvement being a rare occurrence, found in less than 1% of cases. Disseminated carcinomatosis of the bone marrow (DCBM) is characterised by widespread infiltration of cancer cells into the bone marrow, leading to haematological disorders such as disseminated intravascular coagulation and thrombocytopenia. We present a unique case of a man in his late 50s with acute thrombocytopenia as the initial symptom, subsequently diagnosed with gastric cancer on bone marrow examination. Despite receiving chemotherapy, the patient's condition deteriorated rapidly, emphasising the challenging management and poor prognosis associated with DCBM. This case underscores the need for improved diagnostic strategies and therapeutic approaches to enhance patient outcomes in DCBM associated with gastric cancer.

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Publication Details

Journal
BMJ Case Reports
Published
2024-09-01
DOI
https://doi.org/10.1136/bcr-2024-260217
Citations
1
Primary Topic
Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.28
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article

Metastatic gastric adenocarcinoma discovered in the bone marrow

Ekaterina Proskuriakova, Paramjeet Khosla, Vaisny Balamurali, Anuradha Hooda
1 citations
BMJ Case Reports
Cancer Diagnosis and Treatment
0.28
article

Metastatic gastric adenocarcinoma discovered in the bone marrow

Ekaterina Proskuriakova, Paramjeet Khosla, Vaisny Balamurali, Anuradha Hooda
article en
1 citations

Abstract

Gastric cancer primarily metastasizes to the peritoneum, liver and lungs, with bone marrow involvement being a rare occurrence, found in less than 1% of cases. Disseminated carcinomatosis of the bone marrow (DCBM) is characterised by widespread infiltration of cancer cells into the bone marrow, leading to haematological disorders such as disseminated intravascular coagulation and thrombocytopenia. We present a unique case of a man in his late 50s with acute thrombocytopenia as the initial symptom, subsequently diagnosed with gastric cancer on bone marrow examination. Despite receiving chemotherapy, the patient's condition deteriorated rapidly, emphasising the challenging management and poor prognosis associated with DCBM. This case underscores the need for improved diagnostic strategies and therapeutic approaches to enhance patient outcomes in DCBM associated with gastric cancer.

BMJ Case ReportsVol. 17(9)
Mount Sinai Hospital (US), Ross University School of Medicine (BB)
No poverty
Openalex Percentile: Top 36%
Cancer Diagnosis and Treatment
0.28
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